surface protein-2

 MSP2, is another second important GPI anchored
merozoite surface protein with approximately 25 kDa  (Gilson et al., 2006).
MSP2 is another leading candidate antigen subunit of P. falciparum for
malaria vaccine (Happi et al., 2004).
It consists of highly polymorphic central repeats flanked with conserved N- and
C-terminal domains unique variable domains. The MSP-2 has generally two alleles
types, FC27 and 3D7, with different dimorphic structure considerably of the
variable central region, block-3 . The specific region of strains is consists
of repeating units; 3D7 allele  contain
repeating units of Ser, Gly and Ala, while FC27 allelic  forms contain 32-, 12- and 8-mer sequence
repeats. Both allelic forms of MSP2 are basically unstructured, but full length
recombinant proteins under physiological conditions make fibrils (Adda et
al., 2009). Fibril development is mediated through the region of N-terminal
(Low et al., 2007) and this region may also have the properties membrane
interaction(Zhang et al. 2008). It is called whether native fibril like
form of  MSP2 or other complexes;
however, there is some evidence that MSP2 oligomers are placed on merozoites
surface with a number of  MSP-2
interactions molecules being hypothesized (Yang et al., 2010). Recent
studies recommend that the MSP-2, N-terminal region may interact with the lipid
membrane of the merozoite surface (MacRaild et al,. 2012 ; (Adda et
al., 2009)). MSP2 appears to be important for invasion and during invasion retained
on the surface and  soon after degraded when
invasion is complete. However, its exact character is unknown, and no interaction
of receptor ligand or fixing of MSP2 to RBCs have been defined.  MSP-1 and
MSP- 2 genes  because of polymorphic
characters  have been characterized as
polymorphic markers in studies of malaria transmission dynamics in natural
isolatesof P. falciparum (Ferreira
et al., 2007 ; (Boyle et al., 2014)