Antigen Presenting cells

What would you expect of a decrease in the number of cytotoxic T cells? Which type of immunity would it affect? A decrease in the number of cytotoxic T cells can essentially impair a person’s cell-mediated immunity.

Since cytotoxic T cells directly attack foreign substances such as bacteria, viruses, or foreign tissues in the body like a tumor, a decrease in their number could significantly affect a person’s ability to resist these foreign substances and make him or her susceptible to diseases or sicknesses. (Can you tell me where cytotoxic T cells are produced/) Cytotoxic T cells are produced in the Thymus.These cells are developed from their precursor hematopoietic stem cells which are produced in the bone marrow.

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What if there were a lack of helper T cells and how would that affect anti-body mediated responses? If there were a lack of T helper cells, the response of a human to extracellular pathogens would be affected since T-Helper cells are responsible for recognizing a foreign antigen, stimulating antibody production in response to that foreign antigen and producing cytokines which activate other T Cells.(Which of the white blood cells produce antibodies? ) Basically, among all the white blood cells, it is the Lymphocytes that produce antibodies. For example, a human body would respond more weakly to certain bacteria since there is abnormal production of antibodies (What component of the plasma is the antibody? ) The component of the plasma that is an antibody is the immunoglobulin portion and also decrease production of macrophages. (Can you tell me why thre is a decrease in macrophages).An lack of T- helper cells will cause a decrease in macrophages since macrophages present the antigen of the pathogen they have digested to T-helper cells. So if there is a lack of T helper cells, there would also be less macrophages that would serve as Antigen Presenting cells. In effect, a human would be more vulnerable to baecterial infections and other diseases.

Moreover, a lack of T-helper could probably mean HIV infection, which causes a decrease in the number of T-helper cells and ultimately lead to AIDS. (Whichof the cells above has the designation of CD-4? ) T- helper cells have the designation of CD-4.