The 2005 L-Citrulline Reduces Time to Exhaustion and Insulin Response to a Graded Exercise Test journal article, authored by Robert C. Hickner et al, has a number of significant positive qualities. To begin with, the study described through the article effectively does away with the previous misconception that treadmill exhaustion time increases after a subject ingests L-Citrulline (Hickner, 2005). After presenting the hypothesis that L-Citrulline ingestion leads to increased treadmill exhaustion time, the authors systematically work to show that this hypothesis is erroneous through a logical research undertaking. This approach is commendable as it is characteristic of focused and objective research that seeks to unearth original knowledge. Further, the authors are bold and honest enough to state that further research is needed in certain areas where their research undertaking has not proven conclusive.
For example, owing to the existence of a wide array of somewhat conflicting information regarding the effect that L-Citrulline has on treadmill running time, the authors warn that it is not possible to generalize all these findings. This aspect shows that the authors, and their article, have the traits of real scientific researchers. On the other hand, the study observes necessary research ethical principles by informing subjects of the study’s details. Related to this concept, the subjects are recruited and studied based on their voluntary and informed consent. Through this approach, the researchers were careful to uphold established research ethics. Conversely, adequate control mechanisms were implemented to enhance the integrity of the research. For example, a placebo group of subjects was only given the finishing three-gram L-Citrulline dose, thus acting as an effective control group. This action was taken after a first group was given a total of nine grams of L-Citrulline for a period of twenty-four hours.
From the foregoing discussion, it is thus evident that the authors of this article have not only discovered novel information, but have also adhered to established research principles while conducting their study.
Hickner, R. C., et al. (2005). L-Citrulline reduces time to exhaustion and insulin response to a graded exercise test. American College of Sports Medicine, 660-667.